NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Since the Recalcitrant Cancer Research Act was signed into law in 2013, when $101 million was dedicated to the disease, NCI research funding for pancreatic cancer has increased markedly. Gestational trophoblastic disease (GTD) 47. The disease is very hard to detect early and currently there is no screening test available. Location: 13 locations, An open-label, Phase 1 / 2a study of HPN536 as monotherapy to assess the safety, tolerability and PK in patients with advanced cancers associated with mesothelin expression. Location: 204 locations, This phase II trial studies whether adding pembrolizumab to olaparib (standard of care) works better than olaparib alone in treating patients with pancreatic cancer with germline BRCA1 or BRCA2 mutations that has spread to other places in the body (metastatic). Drugs used in chemotherapy, such as gemcitabine hydrochloride, nab-paclitaxel, fluorouracil, leucovorin calcium, and liposomal irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. To find a safe dose of LMB-100 plus tofacitinib in people with pancreatic cancer, bile-duct cancer, and other solid tumors that make mesothelin. Salivary gland type tumors of head and neck, lip, esophagus, stomach, trachea and lung, breast and other location (closed to accrual) 4. Researchers are looking at the potential of new drugs, ways to combine standard drugs, and new therapies to give to patients. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. Our syndication services page shows you how. Tumor of unknown primary (Cancer of Unknown Primary; CuP) (closed to accrual 12 / 22 / 2017) 33. Angiosarcoma 51. Location: 9 locations, Treatment Clinical Trials for Pancreatic Cancer, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Late Effects of Childhood Cancer Treatment, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Tech Transfer & Small Business Partnerships, Step 1: Application Development & Submission, How to Work With Your Health Insurance Plan, Questions to Ask about Treatment Clinical Trials, Drugs Approved for Different Types of Cancer, Drugs Approved for Conditions Related to Cancer, Targeted Therapy Directed by Genetic Testing in Treating Patients with Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial), Nivolumab and Ipilimumab in Treating Patients with Rare Tumors, Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel with 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients with Pancreatic Cancer That Has Spread, Testing the Use of the Usual Chemotherapy before and after Surgery for Removable Pancreatic Cancer, Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients with Pancreatic Cancer That Has Spread with Inherited BRCA Mutations, Testing the Combination of Anetumab Ravtansine With Either Nivolumab, Nivolumab and Ipilimumab, or Gemcitabine and Nivolumab in Advanced Pancreatic Cancer, Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1 / 2 / 3 (Trk A / B / C), ROS1, or ALK Gene Rearrangements (Fusions), A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens. In this trial, people with cancer are assigned to receive treatment based on the genetic changes found in their tumors through genomic sequencing and other tests. Bronchoalveolar carcinoma lung. Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07 / 27 / 2018) 2. Clinical trials at the NIH Clinical Center are open to … Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. However such drugs are now becoming available, such as a drug that targets a form of RAS that has a mutation called G12C. Location: 16 locations, The objective of this study is to evaluate the safety, tolerability, and antitumor activity of oleclumab (MEDI9447) in combination with or without durvalumab plus chemotherapy in subjects with metastatic pancreatic cancer. Location: 11 locations, This trial will study tisotumab vedotin to find out whether it is an effective treatment for certain solid tumors and what side effects (unwanted effects) may occur. This study may help doctors find out which treatment combination is better at prolonging life in older patients with metastatic pancreatic cancer. This year’s symposium was jointly organized by the NCI Pancreatic Cancer … Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: S1609SC@swog.org] (closed to accrual 03 / 15 / 2019) 34. It conducts clinical trials of novel cancer treatment agents for … Location: 13 locations, This is a Phase 3, randomized, double-blind trial to evaluate the efficacy and safety of neoadjuvant treatment with pamrevlumab or placebo in combination with gemcitabine plus nab-paclitaxel (G / NP) in the treatment of locally advanced, unresectable pancreatic cancer subjects. There is no reliable biomarker for early detection, and the available treatments are ineffective in advanced stages of this disease. The 2017 figure represents the most recent data available from the NCI – and shows a remarkable 900 percent increase since PanCAN’s … Adrenal cortical tumors (closed to accrual 06 / 27 / 2018) 32. Because of the complex nature of pancreatic cancer, many experts believe it’s important for all patients to join a clinical trial, even if they have early-stage disease. If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. The programs listed below are a small sampling of NCI’s research efforts in pancreatic cancer. Chordoma (closed to accrual 11 / 29 / 2018) 31. She is leading a clinical trial testing the combination of LMB-100, a drug developed in CCR by the Pastan Lab that is designed to kill cancer cells, and nab-paclitaxel, a drug used to treat … Although few pancreatic cancer patients have, Researchers have found that drugs blocking the activity of proteins that mediate the effects of RAS, force cancer cells to rely on a way of creating energy called. PARP inhibitors are a type of targeted therapy. Paraganglioma (closed to accrual 11 / 29 / 2018) 26. The following are some of our latest news articles on pancreatic cancer research: View the full list of Pancreatic Cancer Research Results and Study Updates. Pancreatic cancer clinical trials are necessary to determine whether new treatments developed in the … Desmoid tumors 28. This phase I / II trial studies the side effects and best dose of BMS-813160 when given together with nivolumab and to see how well they work with or without GVAX following chemotherapy and radiation therapy in treating patients with pancreatic cancer … Pancreatic cancer is the cause of 7.3% of the cancer deaths in the United States. Pancreatic cancer can form in exocrine cells and neuroendocrine cells. Developing drugs that target mutant forms of RAS has proved challenging. Peritoneal mesothelioma (temporarily closed to accrual 05 / 08 / 2020) 41. Small cell carcinoma of the ovary, hypercalcemic type 49. Endometrial carcinosarcoma (malignant mixed Mullerian tumors) (closed to accrual) 45. Pancreatic SPOREs. Clinical trials look at new ways to prevent, detect, or treat disease. The majority of pancreatic cancer research funding comes from the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH), the primary federal agency charged with biomedical research. Welcome to the Translational Research Program (TRP) The Translational Research Program (TRP) is the home of the SPOREs — the Specialized Programs of Research Excellence — a cornerstone of NCI’s efforts to promote collaborative, interdisciplinary translational cancer research. Extrahepatic cholangiocarcinoma and bile duct tumors (closed to accrual 03 / 20 / 2018) 11. PanCAN drives legislative support for increased federal research funding, which is critical because 80 percent of all pancreatic cancer research funding comes from federal sources. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. The addition of pembrolizumab to the usual treatment of olaparib may help to shrink tumors in patients with metastatic pancreatic cancer with BRCA1 or BRCA2 mutations. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This page highlights some of the latest research in pancreatic cancer, including clinical advances that may soon translate into improved care, NCI-supported programs that are fueling progress, and research findings from recent studies. The National Cancer Institute (NCI) is the federal government's principal agency for cancer research and training. NCI also funds cross-cutting initiatives such as cancer centers and funds programs to develop a strong workforce of cancer … NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Vulvar cancer (temporarily closed to accrual) 36. Gastrointestinal stromal tumor (GIST) (closed to accrual 09 / 26 / 2018) 38. The patient is a carrier of a confirmed BRCA1, ATM or HNPCC (hereditary non-polyposis colorectal cancer or Lynch syndrome, hMLH1, hMSH2, PMS1, hMSH6, EpCAM) gene mutation, and there is > 1 pancreatic cancer … Location: 10 locations, This is a phase 1 / 1b study of TTX-030, an antibody that inhibits CD39 enzymatic activity, leading to accumulation of pro-inflammatory adenosine triphosphate (ATP) and reduction of immunosuppressive adenosine, which may change the tumor microenvironment and promote anti-tumor immune response. These proteins help repair damaged deoxyribonucleic acid (DNA) and, therefore, play a role in ensuring the stability of each cell’s genetic material. A postdoctoral research position is available in the laboratory of Dr. Christine Alewine in the Clinical Translation Unit, Laboratory of Molecular Biology (LMB), CCR, NCI, NIH, Bethesda, MD. Adenoid cystic carcinoma (closed to accrual 02 / 06 / 2018) 35. Only 7% are expected to survive 5 years or longer because the disease is … This trial will study the safety, tolerability, pharmacokinetics, and anti-tumor activity of TTX-030 as a single agent and in combination with an approved anti-PD-1 immunotherapy and standard chemotherapies. Location: 12 locations, The purpose of this study is to evaluate the tolerability and safety profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab in participants with locally advanced (unresectable) or metastatic solid tumors; characterize the pharmacokinetic profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab and determine the recommended Phase 2 dose (RP2D) of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab. Patients will be assigned to different baskets according to tumor type and gene fusion. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Location: 13 locations, The purpose of this study is to look at the efficacy and safety of Irinotecan liposome injection in combination with other approved drugs used for cancer therapy, namely 5 fluorouracil / leucovorin (5FU / LV) plus oxaliplatin compared to nab-paclitaxel + gemcitabine treatment in improving the overall survival of patients not previously treated for metastatic pancreatic cancer. In our urgent mission to save lives, we attack pancreatic cancer on all fronts: research, clinical initiatives, … Nearly 50,000 Americans will be diagnosed with pancreatic cancer in 2015, according to NIH’s National Cancer Institute (NCI). Standard treatment for pancreatic cancer usually consists of surgery, chemotherapy, radiation, or combinations of each, depending on the cancer’s stage. Anetumab attaches to mesothelin positive cancer cells in a targeted way and delivers DM4 to kill them. Skip to main content 1-800-4-CANCER Live Chat Publications Dictionary Established under the National Cancer Institute Act of 1937, NCI is part of the National … Gemcitabine hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as fluorouracil, irinotecan, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. NCI funds and oversees both early- and late-phase clinical trials … Neuroendocrine carcinoma including carcinoid of the lung (closed to accrual 12 / 19 / 2017) 24. Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03 / 30 / 2018) 14. Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non-seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. Clinical trials are research studies that investigate new treatments or new combinations of treatments. Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel (PANOVA-3), A Study of BMS-813160 in Combination With Chemotherapy or Nivolumab in Patients With Advanced Solid Tumors, Study of NGM120 in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy, Study of HPN536 in Patients With Advanced Cancers Associated With Mesothelin Expression, A Study of ASP1948, Targeting an Immune Modulatory Receptor, in Subjects With Advanced Solid Tumors, Evaluation of Efficacy and Safety of Neoadjuvant Treatment With Pamrevlumab in Combination With Chemotherapy (Gemcitabine and Nab-paclitaxel) in Locally Advanced Pancreatic Cancer, A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion, A Study to Assess the Effectiveness and Safety of Irinotecan Liposome Injection, 5-fluorouracil / Leucovorin Plus Oxaliplatin in Patients Not Previously Treated for Metastatic Pancreatic Cancer, Compared to Nab-paclitaxel+Gemcitabine Treatment, A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3), A Study of XmAb®22841 Monotherapy & in Combination w / Pembrolizumab in Subjects w / Selected Advanced Solid Tumors, Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors, A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer), A Phase 2 Study of Cediranib in Combination with Olaparib in Advanced Solid Tumors, A Phase 1 / 2 Study of CYT-0851, an Oral RAD51 Inhibitor, in B-Cell Malignancies and Advanced Solid Tumors, TTX-030 Single Agent and in Combination With Immunotherapy or Chemotherapy for Patients With Advanced Cancers, A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies, U.S. Department of Health and Human Services. Find an NCI-supported clinical trial—and learn how to locate other research studies—that may be right for you or a loved one. Giving chemotherapy before and after surgery (perioperative) may work better in treating patients with pancreatic cancer compared to giving chemotherapy after surgery (adjuvant). Pancreatic cancer is often diagnosed at an advanced stage, for people usually have no symptoms until the cancer has already spread to other organs. As part of the Case Comprehensive Cancer Center, UH Seidman Cancer Center is a leading cancer research center and offers many clinical trials for patients with pancreatic cancer.This means that our patients have access to new and innovative therapies that are offered at few other cancer … Location: 11 locations, This is a Phase 1, multiple dose, ascending-dose escalation study and expansion study designed to define a maximum tolerated dose and / or recommended dose of XmAb22841 monotherapy and in combination with pembrolizumab; to assess safety, tolerability, pharmacokinetics, immunogenicity, and anti-tumor activity of XmAb22841 monotherapy and in combination with pembrolizumab in subjects with select advanced solid tumors. Research … clinical trials look at new ways to prevent, detect or. Of PARP, a protein that helps repair damaged DNA you would like to some! Multiple myeloma / 26 / 2018 ) 31 may stop the growth of cells... Accrual 04 / 29 / 2018 ) 10 in deciding if one right. 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